Free Access
Issue
J. Chim. Phys.
Volume 95, Number 2, February 1998
Page(s) 454 - 459
DOI https://doi.org/10.1051/jcp:1998116
DOI: 10.1051/jcp:1998116


J. Chim. Phys. Vol. 95, N°2  p. 454-459

The preliminary solution structure of human p13 MTCP1, an oncogenic protein encoded by the MTCP1 gene, using 2D homonuclear NMR

L. Guignard1, Y.-S. Yang1, A. Padilla1, C. Boiteau1, M.-P. Strub1, F. Hoh1, M.-H. Stern2 and C. Roumestand1

1  Centre de Biochimie Structurale, UMR 9955 du CNRS, INSERM-U414, Université de Montpellier I, Faculté de Pharmacie, 15 avenue Charles Flahault, 34060 Montpellier cedex 1, France
2  Unité INSERM U462, Hôpital Saint-Louis, 75475 Paris, France

Abstract
The human oncogenic protein p13 is coded by the gene MTCP1 which is expressed on mature prolymphocytic leukemias. We investigate its 3D structure using 2D homonuclear NMR. The main secondary structure elements found in p13 MTCP1 are antiparallel $\beta$-sheets which fold in an eight-stranded orthogonal $\beta$-barrel.

Résumé
La protéine oncogénique humaine est codée par le gène MTCP1, exprimé dans des leucémies prolymphocytaires à phénotype mature. Sa structure 3D a été résolue par RMN 2D homonucléaire. p13 MTCP1 est essentiellement composée de feuillets $\beta$ antiparallèles qui s'organisent en un tonneau $\beta$ orthogonal a huit brins.


Key words: 2D NMR -- Protein Structure -- Molecular Modelisation -- Leukemias
Contents

© EDP Sciences 1998

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