Issue |
J. Chim. Phys.
Volume 93, 1996
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Page(s) | 224 - 230 | |
DOI | https://doi.org/10.1051/jcp/1996930224 | |
Published online | 29 May 2017 |
Recherches à conseiller pour l'application de la stérilisation ionisante des médicaments
Université catholique de Louvain, École de pharmacie, unité CHAM 7230, av E-Mounier, 72, 1200 Bruxelles, Belgique.
Cette mise au point pose les problèmes de la radiostérilisation de médicaments à savoir : pourquoi utiliser les rayonnements ionisants, quels sont les obstacles à surmonter, comment procéder à l'irradiation et enfin comment contrôler le traitement.
Abstract
The radiation treatment of bulk quantities with the transport system causes special difficulties like reliable dosimetry, dose-effect relationship, homogeneity of dose distribution, allowable ratio between the maximum and the minimum doses, modified atmosphere packaging, ... All irradiated drugs undergo flavour and color changes, it is important to continue the collection of radiolytic by products and the investigations about the chemistry of these products and to expand the toxicological studies. Improvement of microbiological safety, shelflife extension and replacement of chemical treatment for heat sensitive drug, are some reasons for radiosterilization!
Mots clés : radiostérilisation / médicaments solides / solides moléculaires / application industrielle
© Elsevier, Paris, 1996