Free Access
J. Chim. Phys.
Volume 96, Number 1, January 1999
Page(s) 93 - 100
J. Chim. Phys. Vol. 96, N°1  p. 93-100
DOI: 10.1051/jcp:1999115

Dose and dose rate dependency of lipid peroxide formation in rat tissues by low level contamination with tritiated water

Moisoi N. and Petcu I.

Institute of Physics and Nuclear Engineering, Department of Experimental Physics, P.O. Box MG-6, R-76900, Magurele - Bucharest, Romania

The changes in peroxide level in different tissues (liver, kidney, small intestine, spleen, bone marrow) of rats exposed to low levels of tritiated water were investigated in relation to tissue radiosensitivity, the irradiation dose and the dose rate domain. The radiation exposure was performed by internal contamination of rats with tritiated water, in the 0 – 50 cGy dose domain, with dose rates in the range of 0.01 – 2 cGy/day. For the lower dose rates (< 0.35 cGy/day) the peroxide levels did not increase for doses up to 10 cGy, while a dose rate of 1–1.75 cGy/day induced an increase in peroxide levels starting at 5 cGy. The increases were more significant for the tissues with higher radiosensitivity: spleen, small intestine and bone marrow. For the 4.2–7 cGy dose domain and very low dose rates, up to 0.1 cGy/day, the peroxide level seemed to have an inverse dose rate dependency.

Nous avons étudié la modification du niveau des peroxydes lipidiques pour des tissus ayant des radiosensibilités différentes (foie, rein, rate, intestin grêle, moelle osseuse) après irradiation de rats par contamination interne à l'eau tritiée dans le domaine des faibles doses (0 - 50 cGy) et faibles débits de doses (0,01 - 2 cGy/jour). L'irradiation au débit de dose inférieure à 0,35 cGy/jour, n'augmente le niveau de peroxydation que pour des doses supérieures à 10 cGy. Par contre, le débit de 1-1.75 cGy/jour induit une augmentation significative du paramètre étudié à partir de la dose de 5 cGy. Cette augmentation est plus accentuée pour la rate, l'intestin grêle et la moelle osseuse. Aux doses de 4,2-7 cGy et débits de doses très faibles (< 0.1 cGy), le niveau de peroxydation montre une dépendance inverse par rapport au débit de dose.

Key words: tritiated water, radiosensitivity, dose, dose rate

© EDP Sciences 1999

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