Free Access
J. Chim. Phys.
Volume 95, Number 4, April 1998
Page(s) 830 - 831
DOI: 10.1051/jcp:1998206

J. Chim. Phys. Vol. 95, N°4  p. 830-831

Cinétique de l'apoptose induite après irradiation $\alpha$ in vitro de macrophages alvéolaires de rat

C. Lizon, J.L. Poncy and P. Fritsch

CEA, DSV/DRR/SRCA, Laboratoire de Radiotoxicologie, BP. 12, 91680 Bruyères-le-Châtel, France

After in vitro $\alpha$-particle irradiation of rat alveolar macrophages, apoptosis and necrosis induction have been quantified. Results show a different radiosensitivity depending on time after cell plating and a maximal apoptosis frequency which occurred 48 hours after the end of irradiation.

L'induction d'apoptose et de nécrose a été quantifiée d'après irradation $\alpha$ in vitro de macrophages alvéolaires de rats. Les résultats montrent une radiosensibilité dépendante du temps de culture et l'apparition d'un pic d'apoptose 48 heures après la fin de l'irradiation.

Key words: irradiation alpha -- macrophage alvéolaire -- in vitro -- apoptose -- nécrose

© EDP Sciences 1998

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